Although approved by the FDA only for heavy metal poisoning, the National Institutes of Health have been conducting clinical trials for EDTA chelation for treatment of heart disease. Considered anecdotal, some doctors and complementary health practitioners have successfully used chelation therapy to treat heart disease and stroke by reopening arteries clogged with plaque. Once the EDTA binds to the calcium, the plaques are swept away as the medicine moves through your bloodstream and excreted through your urine. The treatment often includes the administration of high doses of antioxidant vitamin and mineral supplements. Practitioners (Physicians, Naturopaths, Biological Dentists, and Nurse Practitioners) are trained and certified by the American Board of Clinical Metal Toxicology or the American College for Advancement in Medicine. This less expensive alternative to coronary artery bypass surgery, angioplasty, and other conventional medical treatments remains controversial and is usually not covered by health insurance.